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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described as focusing on practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Pragmatic is a software company that provides a variety of casino games for online gambling platforms. Pragmatic's iGaming solutions are used by the top operators and land-based casinos. The company provides front-end tools for design, analysis, promotions, marketing and payment systems, as well as security, customer service, and bug reporting. The company also provides an environment that is safe and secure with high-quality graphics, games and security.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and had participants from different geographic areas. This kind of heterogeneity, which is vital for pragmatic trials to be valid and lessen the chance of bias, is also necessary. However, too much heterogeneity can cause issues with the design of the trial.

Pragmatic Play is a major player on the live casino market offers an array of traditional table games like Blackjack and Roulette. The live studios of the company in Romania and Malta provide customers with an authentic gaming experience as well a full variety of betting options via virtual. The company has also developed several interactive game shows to make online gambling enjoyable. Some of these shows feature live hosts, while others are hosted by celebrities from the industry.

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Pragmatic Play, a relatively young player in the industry of online casinos, has gained an enviable reputation for its slot machines that are mobile-friendly. Their games are optimised for mobile devices and operate on HTML5 technology. They are also regulated and certified by trusted gaming authorities, which ensure fairness and transparency. This is a great indicator for players because it indicates that the games have been tested and validated in order to ensure the randomness and fairness of every round.

In addition to their mobile-friendly slot machines, Pragmatic Play also offers tables games and live dealer casinos. Pragmatic Play is licensed by a variety of regulatory bodies which include Malta Gaming Authority and UK Gambling Commission. The games offered by the company are secured with high-end encryption and its security staff is available to assist players with any issues.

Pragmatic Play's slot games are a hit among both newcomers and seasoned players. They have modern designs and traditional themes. Many of them offer progressive jackpots and have multiple bonus rounds and paylines. They are not volatile so you can enjoy a long gaming experience.

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Legality

Pragmatic Play has earned a name for itself by providing high-quality games and a superior user experience. Its software is designed to work on mobile devices and is compatible with various languages. It has been recognized as one of the most popular gaming platforms for casinos despite its relative infancy. Wolves is one of the latest games which is a five-reel slot machine with a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to replicate real-life scenarios and to achieve maximum credibility externally. They are usually commissioned by practitioners and policy makers to aid in their decision-making. They can also be used to assess the cause-effect relationship of an intervention and its results. They should not, however, be used to replace the need for explanation studies.

The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the elements of a pragmatic research study which includes recruitment, design, delivery of the intervention and its follow-up.

There is a positive increase in the number of pragmatic trials published. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, as shown in red in Figure 2. This is an indication that the health science community is becoming more acquaint to the subject of pragmatism. However, it is important to note that the majority of these studies were conducted in primary care settings.