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Pragmatic trials are those that are designed to inform real-world clinical practice. They are usually focused on the practical aspects of study design, such as the recruitment and consent process in adherence, as well as the use of commonly available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and included participants from various geographical areas. This kind of heterogeneity is essential for practical trials to be valid and also helps reduce bias in the results. Too much heterogeneity, however could cause issues with the trial design.

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The goal of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They can be used to determine the causal relationship between an intervention and its results. However, they should not, be used to replace the need for 프라그마틱 슬롯 하는법 explanation studies.

The pragmatism concept is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the elements of a pragmatic trial that include the recruitment process, the design and implementation of the intervention, and the follow-up.

The number of pragmatic trials is growing. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the subject of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.