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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually characterized by a focus on the practical aspects of study design, such as recruitment and consent as well as adherence to the use of commonly available equipment.
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RTP
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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for a pragmatic trial to be reliable and to reduce bias in the results is also essential. Too much heterogeneity, however, can cause problems with the trial design.
Pragmatic Play Pragmatic Play, one of the major players in the live casino market, offers an array of traditional table games such as Blackjack and Roulette. The live studios of the company in Romania and Malta offer customers an authentic gambling experience, as well as a broad variety of betting options via virtual. The company also offers a variety of games which make online gambling enjoyable and engaging. Some of these shows have live hosts, whereas others are hosted by famous personalities from the industry.
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In addition to their mobile-friendly slot machines, Pragmatic Play also offers table games and live dealer casinos. Pragmatic Play is licensed by several regulatory bodies, including Malta Gaming Authority and UK Gambling Commission. The games offered by the company are protected by high-end encryption and its security team is on hand to assist players with any issues.
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Legality
Pragmatic Play is renowned for its top-notch games, and for providing a superior user experience. The software is available on mobile devices and in a variety of languages. It has established itself as one of the most popular gaming platforms in the casino industry despite its relatively young age. The latest releases include Wolves 5 reel video slot with a healthy RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.
The goal of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They are also a good method to determine the causality between an intervention and its results. They should not, however be used to replace explanatory studies.
The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform the policy and practice of. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool attempted to define the features of a pragmatic study, including the recruitment process, the design and implementation of the intervention, and the follow-up.
The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to keep in mind, however, that the majority of these studies were conducted in primary-care settings.